Repositioning of FDA-approved drugs for the treatment of methicillin-resistant Staphylococcus aureus infection: Structure-based virtual screening and in vitro assay

Background: Computer-aided repositioning of approved drugs is an increasingly popular strategy for the discovery of effective therapies. The potency of the newly repositioned drugs can be optimized using them as a component of an effective drug combination, thereby achieving the desired therapeutic effect at a lower and more tolerable drug concentration. Aim and Objectives: The aim of the study was to perform structure-based virtual screening and repurposing of FDA-approved drugs for the treatment of methicillin resistance by Staphylococcus aureus (SA) and perform an in vitro validation of the prediction. Materials and Methods: Following ethical clearance at the Department of Pharmacology and Therapeutics, College of Health Sciences, Usmanu Danfodiyo University Sokoto, molecular docking was performed against 5 validated protein targets involved in the development of methicillin resistance by SA and an in vitro validation of the prediction was done using 3 of the top-ranking drug candidates against methicillin-resistant vancomycin-susceptible strain of the pathogen (ATCC 43300). Results: Desmopressin and docetaxel, two of the 20 top-ranking repurposed drugs discovered through virtual screening, enhanced the inhibitory effect of oxacillin against the ATCC 43300 SA strain in a ratio-dependent manner, although each of the two drugs singly was only weakly effective against the bacterial strain. The standard drug, vancomycin (also among the top-scoring candidates), alone, was effective against ATCC 43300 strain and in combination with oxacillin, the two drugs produced a ratio-dependent synergistic effect against the bacterial strain. Conclusion: These findings suggest that oxacillin-based combinations with desmopressin, docetaxel, and the standard drug vancomycin, three of the 20 top-ranking drugs, at optimum ratios, may be beneficial in reversing the resistance of the ATCC 43300 SA strain to oxacillin, thus supporting the prediction of the molecular docking results.

The Status and Trends of Food Fraud in Tamale, Ghana

Despite its seriousness, food fraud has not received the necessary attention in Ghana’s discourse on food safety. Food fraud is generally considered as the intentional misrepresentation of the contents or identity of food for economic gain. The study was aimed at assessing the food fraud awareness level of participants as well as the foods most likely to be implicated in food fraud cases in Tamale, Ghana. Data was collected from 385 participants, including food business operators and consumers, via a simple random sampling technique using a structured questionnaire. Most participants (54%) were not aware of food fraud and its related activities before the study. Beverages and juices, fruits and vegetables, spices, oils, meat and fish, baked foods, honey, milk, and semi-processed local foods such as groundnut paste, "Dawadawa," “Kulikuli zim,” and “Agushi powder” were all revealed to be implicated in food fraud by respondents. Adulteration was the most common food fraud action, but tampering, substitution, and mislabeling were also identified as ongoing in the study area. “Moora” (Bixa orellana seeds) was revealed as the key adulterant used in most foods. Food fraud, which is a threat to consumer health and well-being, is active in the region and is predicted to increase without strict regulation and increased sensitization about its dangers. The fight against food fraud should be refocused on making food defense systems like vulnerability analysis and critical control points (VACCP) a key aspect of food safety systems to tackle food fraud.

Sex-related differential prevalence of central obesity in diabetes mellitus: a multi-centred survey in North-Central Nigeria

Contrary to the old dictum that central obesity is more common among men than women, recent reports have shown a gradual reversal of this trend, as suggested by some studies. Objective: To compare the prevalence of central obesity among men and women with Diabetes mellitus in NorthCentral Nigeria. Methods: This multi-centred, cross-sectional study was conducted across 20 hospitals in Abuja, Nasarawa State, and Niger State, involving 1040 participants. Some obesity indices (body mass index, waist circumference and waist-toheight ratio) were measured. Results: The prevalence of central obesity (waist circumference criterion) was significantly higher in the females compared to male participants (89.6% vs 51.6%, χ2 = 1231.37, p<0.001), similar to the prevalence determined by waistheight ratio criterion (female vs male, 88.8% vs 71.5%, χ2 = 58.83, p<0.001). Following correction for age, duration of diabetes mellitus, blood pressure, blood glucose, and glycated haemoglobin using logistic regression, female gender remained a significant determinant of central obesity (OR = 2.76, 95% CI 1.81-3.83, p = 0.004). Conclusion: The prevalence of central obesity was higher among women than men in a cross-section of patients with diabetes mellitus in North-Central Nigeria

Gender-based violence in a rural Nigerian community during the COVID-19 era: a call for policy action

Introduction: gender-based violence (GBV) is a global pandemic which is deeply rooted in culture, hence the need to contextually understand its occurrence and patterns in rural settings. The objective of this study assessed respondents´ attitude, prevalence, the perceived risk factors, patterns and predictors of GBV in Ife-Odan, Osun State, Nigeria. Methods: cross-sectional study design was used and multi-stage sampling method employed to recruit 450 consenting adults. A pretested interviewer-administered, semistructured questionnaire was used for data collection. Both descriptive and inferential statistics were carried out. Results: mean age (±SD) of the respondents was 30.73±7.0, 58.7% of them were females and 88.0% had negative attitude to GBV. Prevalence of any form of GBV was 16.2%. Predominant GBV types included intimate partner violence (IPV) (58.3%), female genital mutilation (FGM) (31.1%), Sexual violence (6.9%) and incest (3.4%). Perceived risk factors of GBV included cultural acceptance, substance abuse, lack of punishments for GBV offenders, indecent female dressing styles, social media influences, effects of COVID-19 lockdown and male dominance. However, gender (AOR=7.82; 95%CI=2.35-8.17), marital status (AOR=3.23;95%CI=1.82-3.78), religion (AOR=5.02;95%CI=1.78-9.63) and attitude (AOR=4.23; 95%CI=2.267-5.82) were the significant predictors of past GBV experiences in the study setting. Conclusion: gender-based violence (GBV) is prevalent in the study setting, with IPV being the most common. There is need for policymakers to focus on cultural transformation by designing a robust awareness campaign against GBV in rural Nigerian communities. Traditional and religious leaders should be sensitized and involved in the campaign programs using all available channels of communication. Laws prohibiting perpetration of GBV need to be fully implemented.

Utilization of modern family planning methods among women of reproductive age group in North-Central Nigeria; rural – urban comparison

Introduction: Contraception is one of the most successful developmental interventions, unique in women empowerment and population control. Family planning (FP) reinforces the right to determining the number and spacing of children. Hence, we determine the utilization of modern FP methods among urban and rural dwellers. Material and Methods: This is a cross-sectional study of reproductive age women in Lafia, Nigeria. Ten primary healthcare centers (PHCs) each were selected from the urban and rural locations over 6 months using multi-staged sampling technique. Questionnaire was administered, and the data were analyzed using SPSS V 23. P < 0.05 was considered significant. Results: Most participants were aged between 20 and 29 years. The prevalence of using modern methods of FP was 17.3%. More than three quarters of urban women are using contraceptives compared with one quarter of rural women. There was a difference between those who ever used measures to delay pregnancy and their locations, P = 0.049. Women in the rural areas use the cycle beads, while those in the urban areas use the injectables. Need for more children was the most common reason for discontinuing FP, others are FP failure, absence of spouse, and fear of side effects. Age of the participants was found to be a good predictor of using modern FP method, P = 0.022. Conclusion: There is low prevalence of modern FP utilization in this study despite knowing where to access the services (PHCs). Three of four urban women are using FP compared with one out of four among rural women. The cycle beads and the injectables were the most common methods. Age is a major determinant of using FP.

The Sanitary Conditions of Bakeries and Food Safety Practices Assessment of Bakers in Tamale Metropolis, Ghana

There is a lack of research on the safety of bread in Ghana, although it is one of the foods consumed by most Ghanaians daily. The study, therefore, assessed the sanitary conditions of bakeries in the Tamale Metropolis and further evaluated the food safety practices of bakers in these bakeries. The study employed the use of a questionnaire to collect data in 24 carefully selected bakeries and then the food safety practices of bakers in these bakeries. Results showed that 91.7% of the bakeries had bakers wearing protective gears while working. All (100%) the bakeries were free of domestic animals and a visible presence of insects, rodents or vectors. However, 6(25%) bakeries placed their solid waste containers in the bakery premises. Also, 89.5% of the bakers indicated that they always wash their hands with soap and water before working or handling baking ingredients and materials. All (100%) bakers indicated that they check the expiry dates of their bakery ingredients before using them. 29.8% of the bakers, however, did not make it a practice of refrigerating bakery ingredients that require to be stored in the fridge when not in use. In conclusion, most bakeries had good sanitary conditions and were managed in a manner that ensure food safety. Bakers also exhibited a good level of food safety adherence. Managers should continue to ensure that good sanitary standards are followed and food risk analysis concepts like HACCP are implemented in the bakery to check new and complex food safety threats.

Prevalence and factors associated with symptoms of psychological distress among students of Allied Health Sciences in a Nigerian University

BACKGROUND@#A student enrolled in Allied Health Sciences has a curriculum and academic standards that are different compared to a student enrolled in a medical programme. Nevertheless, little is known about the psychological distress of this population. Our objective was to determine whether psychological distress is prevalent in students enrolled in an Allied Health Sciences programme, as well as factors that contribute to it. @*METHODS@#Three hundred and thirty-three (333) undergraduates studying Allied Health Sciences, ages 18-30, were included in this cross-sectional study. A representative sample of students from nursing, physiotherapy, medical laboratory science, medical radiography, and optometry programmes were selected through a stratified sampling technique. A 21-item Depression Anxiety and Stress Scale (DASS-21  10) was used to collect data on psychological distress indicated by depression, anxiety, and stress. We fitted a multivariate logistic regression to identify factors associated with psychological distress among the participants.@*RESULTS@#As a result of the study, 58.9% reported depression, 66.1% reported anxiety, and 45.1% reported stress. Depression (AOR= 3.23; 95% CI: 1.33- 7.81), anxiety (AOR= 3.33;95% CI:1.34- 8.26) and stress (AOR= 2.58;95% CI: 1.14- 5.85) were associated with family history of mental illness. Poor academic performance was associated with anxiety (OR=2.75; 95% CI: 1.35- 5.61) and stress (OR=2.00; 95% CI: 1.05-3.81).@*CONCLUSIONS@#The prevalence of psychological distress among allied health sciences students is high, especially among students with poor academic performance and those with a family history of mental illness. Psychological distress can be prevented with early detection and awareness programmes.

Perceptions of the COVID-19 vaccine and willingness to receive vaccination among health workers in Nigeria

Objectives@#The study aimed to examine health workers’ perceptions of the coronavirus disease 2019 (COVID-19) vaccine in Nigeria and their willingness to receive the vaccine when it becomes available. @*Methods@#This multi-center cross-sectional study used non-probability convenience sampling to enroll 1,470 hospital workers aged 18 and above from 4 specialized hospitals. A structured and validated self-administered questionnaire was used for data collection. Data entry and analysis were conducted using IBM SPSS ver. 22.0. @*Results@#The mean age of respondents was 40±6 years. Only 53.5% of the health workers had positive perceptions of the COVID-19 vaccine, and only slightly more than half (55.5%) were willing to receive vaccination. Predictors of willingness to receive the COVID-19 vaccine included having a positive perception of the vaccine (adjusted odds ratio [AOR], 4.55; 95% confidence interval [CI], 3.50−5.69), perceiving a risk of contracting COVID-19 (AOR, 1.50; 95% CI, 1.25–3.98), having received tertiary education (AOR, 3.50; 95% CI, 1.40−6.86), and being a clinical health worker (AOR, 1.25; 95% CI, 1.01−1.68). @*Conclusion@#Perceptions of the COVID-19 vaccine and willingness to receive the vaccine were sub-optimal among this group. Educational interventions to improve health workers' perceptions and attitudes toward the COVID-19 vaccine are needed.

Recent emergence and outbreak of rotavirus gastroenteritis in Samoa: A scoping review of risk factors, containment measures and public health preparedness

Diarrheal diseases have been known to cause death in many children below the age of five years, and rotavirus infection represents a major health problem in the world today, particularly in developing countries. The recent outbreak of rotavirus gastroenteritis in Samoa led to the introduction of her debut national immunization program on rotavirus vaccination for infants. Despite the introduction of anti-viral and anti-emetic drugs as of the containment approaches towards the virus, risk factors, preventive measures and public health preparedness against rotavirus infection are poorly understood in Samoa. This review aims to use available evidence on rotavirus literature to elucidate and map preventive strategies for the recently emerged rotavirus infections in Samoa. We conducted a search strategy using online medical literature databases and retrieval systems. A designated set of keywords such as rotavirus, gastroenteritis, outbreak, risk factors, containment measures, vaccination and Samoa were inserted in electronic databases to retrieve articles. The databases included PubMed, Google Scholar, MEDLINE, Scinapse, and EBSCO host. Findings from this review addressed the impact of rotavirus infection, associated threats and other preventive measures. Introducing useful health frameworks in pursuing possible methods such as improved water quality, exclusive breast feeding, improved laboratory diagnostics and outbreak surveillance, may be essential in addressing alternate approaches towards containment of the disease in Samoa and other Pacific Island Countries and Territories.

Recent emergence and outbreak of rotavirus gastroenteritis in Samoa: A scoping review of risk factors, containment measures and public health preparedness

Diarrheal diseases have been known to cause death in many children below the age of five years, and rotavirus infection represents a major health problem in the world today, particularly in developing countries. The recent outbreak of rotavirus gastroenteritis in Samoa led to the introduction of her debut national immunization program on rotavirus vaccination for infants. Despite the introduction of anti-viral and anti-emetic drugs as of the containment approaches towards the virus, risk factors, preventive measures and public health preparedness against rotavirus infection are poorly understood in Samoa. This review aims to use available evidence on rotavirus literature to elucidate and map preventive strategies for the recently emerged rotavirus infections in Samoa. We conducted a search strategy using online medical literature databases and retrieval systems. A designated set of keywords such as rotavirus, gastroenteritis, outbreak, risk factors, containment measures, vaccination and Samoa were inserted in electronic databases to retrieve articles. The databases included PubMed, Google Scholar, MEDLINE, Scinapse, and EBSCO host. Findings from this review addressed the impact of rotavirus infection, associated threats and other preventive measures. Introducing useful health frameworks in pursuing possible methods such as improved water quality, exclusive breast feeding, improved laboratory diagnostics and outbreak surveillance, may be essential in addressing alternate approaches towards containment of the disease in Samoa and other Pacific Island Countries and Territories.

Type 2 diabetes mellitus risk assessment among doctors in Ondo state

Introduction: Diabetes Mellitus (DM) has become a disease of public health importance in Nigeria. Early identification of DM risk is important in the reduction of this disease burden. This study assessed ten-year risk of developing type 2 DM among some medical doctors in Ondo State. Methods: This was a cross-sectional study that assessed ten-year risk of developing type 2 DM among some doctors using the Finland Diabetic Risk Score form. Known diabetics were excluded from the study. Body mass index (BMI), waist circumference (WC), blood pressure and total DM risk score were determined for each participant. Results: One hundred and ninety-two doctors participated in the study with a male: female ratio of 1.3:1. Majority (92.2%) were below 55 years, 22 (11.5%) were obese, 32(16.7%) had central obesity, 46(24%) reported physical inactivity, 49(25.5%) had family history of DM, 141(73.4%) do not take fruits and vegetables regularly. Forty-three (22.4%) were found to have elevated blood pressure while 6(3.1%) had elevated blood glucose. Fifty-seven (29.7%) of the participants had increased ten-year DM risk. Significant predictors of increase DM risk were age ≥ 45 years (AOR:9.08; CI 3.13-26.33; p = <0.001 ) ; BMI ≥25kg/m2 (AOR:11.41; CI:4.14-31.45; p = <0.001) ; family history of DM (AOR:9.93; CI:3.25-30.39; p = <0.001) ; abdominal obesity (AOR:6.66; CI:2.08-21.29; p= < 0.001); and infrequent dietary intake of fruits and vegetable(AOR:3.11;CI:1.03:9.37: p = 0.04) Conclusion: There was increased 10-year DM risk in about 30% of the participants. Lifestyle modification such as physical activity and regular consumption of fruits and vegetables should be encouraged among doctors.

Perceptions of the COVID-19 vaccine and willingness to receive vaccination among health workers in Nigeria

Objectives@#The study aimed to examine health workers’ perceptions of the coronavirus disease 2019 (COVID-19) vaccine in Nigeria and their willingness to receive the vaccine when it becomes available. @*Methods@#This multi-center cross-sectional study used non-probability convenience sampling to enroll 1,470 hospital workers aged 18 and above from 4 specialized hospitals. A structured and validated self-administered questionnaire was used for data collection. Data entry and analysis were conducted using IBM SPSS ver. 22.0. @*Results@#The mean age of respondents was 40±6 years. Only 53.5% of the health workers had positive perceptions of the COVID-19 vaccine, and only slightly more than half (55.5%) were willing to receive vaccination. Predictors of willingness to receive the COVID-19 vaccine included having a positive perception of the vaccine (adjusted odds ratio [AOR], 4.55; 95% confidence interval [CI], 3.50−5.69), perceiving a risk of contracting COVID-19 (AOR, 1.50; 95% CI, 1.25–3.98), having received tertiary education (AOR, 3.50; 95% CI, 1.40−6.86), and being a clinical health worker (AOR, 1.25; 95% CI, 1.01−1.68). @*Conclusion@#Perceptions of the COVID-19 vaccine and willingness to receive the vaccine were sub-optimal among this group. Educational interventions to improve health workers' perceptions and attitudes toward the COVID-19 vaccine are needed.

Studies on Comparative Hematological and Biochemical Changes in Yankasa Sheep Experimentally Infected with Trypanosoma vivax and Trypanosoma congolense Field Isolates of Nigerian Origin

Background:African Animal Trypanosomosisis one of the key hindrances to full livestock development in most parts of sub-Saharan Africa, despite years of efforts to eradicate the disease. It is an important parasitic disease of humanand animals. Control of the disease relies majorly on chemotherapy of one of the three trypanocidal drugs. The severity of haematological indices depends on parasite species, host involved and nutrition. Hence, there is need to assess the pathogenicity and compare their effects on some of our local breeds of livestock. Methodology:Field isolates Trypanosoma vivaxand Trypanosoma congolenseof Nigerian origin were used. Thirty sheep were acquired and preconditioned for two weeks in arthropod-proofed pens before the commencement of the experiment. The sheep were divided into five groups (A-T.vivaxinfected-treated, B-T.vivaxinfected-untreated, C-No infection, no treatment, E-T. congolenseinfected-treated and F-T. congolenseinfected-untreated. Packed Cell Volume, serum protein, WBC, DLC were monitored weekly for 8 weeks.Results:There was gradual decreased in PCV of all the infected animals which was an indication of anaemia but more severe in T. vivaxgroups. Also decreased in plasma protein that was more pronounced and prolonged in T. vivaxthan the T. congolensegroups, this was similar with WBC. Neutrophils had initial increased in all the groups before dropping and low value of monocyte at the early period of infections which later disappeared. There was no basophil seen in all the T.vivaxgroups but few were observed in T.congolensegroups. Conclusion: Anaemia is a general feature of most parasitic infections especially in trypanosomosis. Trypanosoma vivaxused in this study is more pathogenic than the T. congolense, hence may have more negative effects in sheep production in author’s environment

Preterm deliveries and progesterone levels in pregnant women attending antenatal care in a health care facility in Sokoto state, Nigeria: a preliminary study

Background: Progesterone related complication during pregnancy is currently being viewed as one of the underlying causes of miscarriages and preterm deliveries. Progesterone assay is often neglected during routine screening in antenatal clinics (ANC) in primary health care centres in Nigeria. This study was designed to monitor 40 volunteer expecting mothers between the ages 18-35 years with a history of child birth and to evaluate serum progesterone levels accordingly for pregnancy in second and third trimesters.Methods: Volunteers were categorized according to their age and stage of pregnancy. Progesterone was estimated in serum collected from each volunteer using ELISA kits (Cayman chemicals, USA).Results: The results showed that age disparity among subjects did not play a role in the observed progesterone levels in both trimesters. Second trimester progesterone levels (37.73±0.32 ng/ml) were closest to lower limits of reference ranges for second trimester pregnancy (25.60-89.40 ng/ml). However, third trimester average serum progesterone levels of 36.31±0.26 ng/ml fell below minimum values of 42.50 ng/ml expected in normal pregnancy. Three preterm deliveries were recorded among the monitored subjects while an incidence rate of 1:32 births was observed for all deliveries received at the facility within the five months period all monitored subjects gave birth.Conclusions: The preponderance of low gestational progesterone constitutes a risk factor to delivery at term. It is recommended that local ANC programme include progesterone monitoring and therapy as an intervention strategy against preterm births.

Assessment of Causes and Effects of Drugs and Substances Abuse among Youth: A Case Study of Katsina Metropolis (North West Nigeria)

Aims:To determine the cause, effect and type of drugs commonly abuse among youth in Katsina metropolis.Study Design:Descriptive cross-sectional design carried out in Katsina metropolis in June to September 2018.Methodology:A descriptive cross sectional design was used for the study where by 384 respondents were selected through a purposive and snowball sampling techniques to select the study subject from the study areas.A validated and structured interviewer administered questionnaire (IAQ) was used to collect data from the respondents. Data was analysed using SPSS version 20.0.Results:Findings from the study showed that peer pressure 75(19.5%) and desire for enjoyment51(13.3%) are the major cause associated with the abuse of drugs by the respondents. The most commonly abused substances by the respondents include Tobacco 112(29.2%), Codeine 68(17.7%) Marijuana (Indian hemp) 55(14.3), and cola nut 17(3.4%) and majority of the respondent Original Research Article perceive negative effect of poor health (madness) 212 (55.2%) as the major effect and aggressive behavior’s 71(18.5%).Conclusion: The major cause of substance abuse among youth are peer pressureand desire for enjoyment, common effect ispoor health and Tobacco is the common abuse drug. It is therefore recommended that Parent should take good care of their children during teenage age and government should control the production and supply of these illicit substances.

Anti-depressant activities of Theobroma cacao Extract on Reserpine-induced Depression in Female Wistar Rats.

Background: Depression is one of the most commontypes of neurological disorder, which is a markedpattern of disturbances in emotional behavior, memoryand hedonic processing. Aim and Objectives: Toinvestigate the role of ethanolic extract of Theobromacacao seed on the prefrontal cortex of female Wistarrats following reserpine-induced depression. Materialand Methods: Thirty-six (36) female Wistar rats wereused for this study. They were divided into six (A - F)groups (n = 6). Group A- control, Group B - 0.2 mg/kgreserpine, Group C - 10 mg/kg fluoxetine, Group D -500 mg/kg Theobroma cacao seed extract, Group E -0.2 mg/kg reserpine + 500mg/kg Theobroma cacaoseed extract, Group F - 0.2 mg/kg reserpine + 10mg/kgfluoxetine. Animals were euthanized via cervicaldislocation after the last day of administration and theprefrontal cortex and hippocampus were excised andfixed in 10% formalin solution for routine histologicalprocessing while the part used for biochemical assaywere homogenized in phosphate buffer beforecentrifugation. Results: Morphological alteration andreduced population of prefrontal cortex andhippocampus neurons, reduced protein synthesis, poorbehavioral patterns, reduced neurotransmission andinduction of oxidative stress in reserpine exposedanimal. Conclusion: Theobroma cacao seed extractwas able to mitigate these aberrations.

Distribution pattern and prevalence of West Nile virus infection in Nigeria from 1950 to 2020: a systematic review / 한국역학회지

OBJECTIVES@#West Nile virus (WNV) is a re-emerging mosquito-borne viral infection. This study investigated the pooled prevalence pattern and risk factors of WNV infection among humans and animals in Nigeria. @*METHODS@#A systematic review was conducted of eligible studies published in PubMed, Scopus, Google Scholar, and Web of Science from January 1, 1950 to August 30, 2020. Peer-reviewed cross-sectional studies describing WNV infections in humans and animals were systematically reviewed. Heterogeneity was assessed using the Cochrane Q statistic. @*RESULTS@#Eighteen out of 432 available search output were eligible and included for this study. Of which 13 and 5 were WNV studies on humans and animals, respectively. Although 61.5% of the human studies had a low risk of bias, they all had high heterogeneity. The South West geopolitical zone of Nigeria had the highest pooled prevalence of anti-WNV immunoglobulin M (IgM; 7.8% in humans). The pooled seroprevalence of anti-WNV IgM and immunoglobulin G (IgG) was 7.1% (95% confidence interval [CI], 5.9 to 8.3) and 76.5% (95% CI, 74.0 to 78.8), respectively. The WNV RNA prevalence was 1.9% (95% CI, 1.4 to 2.9), while 14.3% (95% CI, 12.9 to 15.8) had WNV-neutralizing antibodies. In animals, the pooled seroprevalence of anti-WNV IgM and IgG was 90.3% (95% CI, 84.3 to 94.6) and 3.5% (95% CI, 1.9 to 5.8), respectively, while 20.0% (95% CI, 12.9 to 21.4) had WNV-neutralizing antibodies. Age (odds ratio [OR], 3.73; 95% CI, 1.87 to 7.45; p<0.001) and level of education (no formal education: OR, 4.31; 95% CI, 1.08 to 17.2; p<0.05; primary: OR, 7.29; 95% CI, 1.80 to 29.6; p<0.01) were significant risk factors for WNV IgM seropositivity in humans. @*CONCLUSIONS@#The findings of this study highlight the endemicity of WNV in animals and humans in Nigeria and underscore the need for the One Health prevention and control approach.

Does Arthroscopic Repair of Femoroacetabular Impingement Pathology Affect Clinical Outcomes after Ipsilateral Total Hip Arthroplasty? / 대한고관절학회지

PURPOSE: Arthroscopy for repair of femoroacetabular impingement (FAI) and related conditions is technically challenging, but remains the preferred approach for management of these hip pathologies. The incidence of this procedure has increased steadily for the past few years, but little is known about its potential long-term effects on future interventions. The purpose of this study was to evaluate whether prior arthroscopic correction of FAI pathology impacts postoperative complication rates in patients receiving subsequent ipsilateral total hip arthroplasty (THA) on a national scale.MATERIALS AND METHODS: A commercially available national database – PearlDiver Patients Records Database – identified primary THA patients from 2005 to 2014. Patients who had prior arthroscopic FAI repair (post arthroscopy group) were separated from those who did not (native hip group). Prior FAI repair was examined as a risk factor for complications following THA and a multivariable logistic regression analysis was applied to identify risk factors for complications following THA.RESULTS: A total of 11,061 patients met all inclusion and exclusion criteria; 10,951 in the native hip group and 110 in the post arthroscopy group. Prior FAI repair was not significantly associated with higher rates of 90-day readmission (P=0.585), aseptic dislocation/revision within 3 years (P=0.409), surgical site infection within 3 years (P=0.796), or hip stiffness within 3 years (P=0.977) after THA.CONCLUSION: Arthroscopic FAI repair is not an independent risk factor for complications following subsequent ipsilateral THA (level of evidence: III).

Distribution pattern and prevalence of West Nile virus infection in Nigeria from 1950 to 2020: a systematic review / 한국역학회지

OBJECTIVES@#West Nile virus (WNV) is a re-emerging mosquito-borne viral infection. This study investigated the pooled prevalence pattern and risk factors of WNV infection among humans and animals in Nigeria. @*METHODS@#A systematic review was conducted of eligible studies published in PubMed, Scopus, Google Scholar, and Web of Science from January 1, 1950 to August 30, 2020. Peer-reviewed cross-sectional studies describing WNV infections in humans and animals were systematically reviewed. Heterogeneity was assessed using the Cochrane Q statistic. @*RESULTS@#Eighteen out of 432 available search output were eligible and included for this study. Of which 13 and 5 were WNV studies on humans and animals, respectively. Although 61.5% of the human studies had a low risk of bias, they all had high heterogeneity. The South West geopolitical zone of Nigeria had the highest pooled prevalence of anti-WNV immunoglobulin M (IgM; 7.8% in humans). The pooled seroprevalence of anti-WNV IgM and immunoglobulin G (IgG) was 7.1% (95% confidence interval [CI], 5.9 to 8.3) and 76.5% (95% CI, 74.0 to 78.8), respectively. The WNV RNA prevalence was 1.9% (95% CI, 1.4 to 2.9), while 14.3% (95% CI, 12.9 to 15.8) had WNV-neutralizing antibodies. In animals, the pooled seroprevalence of anti-WNV IgM and IgG was 90.3% (95% CI, 84.3 to 94.6) and 3.5% (95% CI, 1.9 to 5.8), respectively, while 20.0% (95% CI, 12.9 to 21.4) had WNV-neutralizing antibodies. Age (odds ratio [OR], 3.73; 95% CI, 1.87 to 7.45; p<0.001) and level of education (no formal education: OR, 4.31; 95% CI, 1.08 to 17.2; p<0.05; primary: OR, 7.29; 95% CI, 1.80 to 29.6; p<0.01) were significant risk factors for WNV IgM seropositivity in humans. @*CONCLUSIONS@#The findings of this study highlight the endemicity of WNV in animals and humans in Nigeria and underscore the need for the One Health prevention and control approach.

Effectiveness of an Oral Health Education Program to Improve Mothers Awareness of Natal Teeth: A Randomized Controlled Study

Abstract Objective: To evaluate the effectiveness of an oral health talk aided by a video on improving the awareness of mothers about natal teeth in two rural communities in southwest Nigeria. Material and Methods: A cluster-randomized controlled trial was conducted among 80 mothers in two rural communities in Nigeria, randomized into study and control groups. Baseline information was obtained with a pre-tested interviewer administered questionnaire. The mothers in the study group participated in an oral health education program comprising of a video show on natal teeth in addition to an oral health talk. The control group did not receive any intervention. Post-intervention data was obtained three weeks afterwards. Data collected was analyzed with SPSS using paired t-test, independent t-test and Chi-square test. Results: The sociodemographic characteristics of participants in both groups were similar. The mean knowledge, attitude and practice percentage scores for the study group were 38.9 ± 26.3% (pre-intervention) and 73.6 ± 26.2% (post-intervention); while for the control group, the values were 43.2 ± 31.4% (pre-intervention) and 43.9 ± 32.4% (post-intervention). The study group, had a 34% increase in knowledge, attitude and practice percentage score (CI=23.7-45.5; t=6.4; p<0.001), while the control group, had an increase of 0.7% (CI=-0.7-2.2; t=1.00; p=0.323). Conclusion: An oral health education program comprising of oral health talk and a video about natal teeth improved the awareness of mothers about natal teeth as a normal phenomenon.